CA125: Holy Grail or a Poisoned Chalice

Replicating software engineering experiments: a poisoned chalice or the Holy Grail

Undertaking empirical work to understand the software engineering process is an increasingly common activity. However, due to the nature of most software engineering studies, drawing reliable conclusions from a single study is inherently dangerous. A single study will possess a large number of parameters, some controlled, some completely unconstrained. Any one of which can potentially cause a s...

”Semi Parametric Estimation of Long Memory: the Holy Grail or a Poisoned Chalice?”

Considerable previous literature has addressed the problem of finding the most desirable estimator of the long memory parameter in a univariate time series. This paper considers three different estimation procedures: (i) the long memory parameter is obtained from a semi parametric Local Whittle estimator, which is used to filter the series before estimation of the short run parameters, (ii) a t...

The White Paper: opportunity or poisoned chalice?

Pseudokinase drug intervention: a potentially poisoned chalice.

Pseudokinases, the catalytically impaired component of the kinome, have recently been found to share more properties with active kinases than previously thought. In many pseudokinases, ATP binding and even some activity is preserved, highlighting these proteins as potential drug targets. In both active kinases and pseudokinases, binding of ATP or drugs in the nucleotide-binding pocket can stabi...

Pursuing the "Holy Grail".

Over the past decade, several large, randomized trials have allowed us to better define the appropriate population for primary prevention implantable cardioverterdefibrillator (ICD) placement, saving thousands of lives every year. MADIT II (Multicenter Automatic Defibrillator Implantation Trial II) and SCD-HeFT (Sudden Cardiac Death in Heart Failure Trial) have demonstrated a survival benefit o...